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SMILES Nc1ncnc2n(nc(Cc3cccc4ccccc34)c12)C1CCNCC1

InChI Key InChIKey=OTWGEGUQDHMDBA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50345711   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington.

Curated by ChEMBL
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of Toxoplasma gondii recombinant N-terminal hexahistidine tagged CDPK1 expressed in Escherichia coli using syntide-2 as substrate after 90...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8FV5PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington.

Curated by ChEMBL
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B56MVCUS Patent
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through its Center for Commercialization

US Patent
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B56MVCUS Patent
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO

US Patent
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D79DSFUS Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington.

Curated by ChEMBL
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D79DSFUS Patent
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K077GQUS Patent
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO

US Patent
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D79DSFUS Patent
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K077GQUS Patent
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K077GQUS Patent
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K077GQUS Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington.

Curated by ChEMBL
LigandPNGBDBM50345711(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D79DSFUS Patent