null
SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCN(CC1)C1COC1
InChI Key InChIKey=XDTMZEAHVJVNJG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50352760
Affinity DataIC50: 7.15nMAssay Description:ALK-inhibiting activity was measured by following an activity of inhibiting phosphorylation by biotinylated peptide (EGPWLEEEEEAYGWMDF). For the dete...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of INSR activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCA activity by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Raf-1 activity assessed as MEK1/2 phosphorylationMore data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCb2 activity by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Aurora-A activity by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of AKT1 activity by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HER2 activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF1R activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FGFR2 activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRC activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MET activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KIT activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDR activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL activity by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MET using Bio-HER2tide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KIT using Bio-HER2tide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDR using Bio-Gastrintide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCb2 activity by fluorescence polarization assayMore data for this Ligand-Target Pair