null
SMILES CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12
InChI Key InChIKey=ZYQXEVJIFYIBHZ-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 39 hits for monomerid = 50358430
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of N-terminus flag-tagged LynB expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated fo...More data for this Ligand-Target Pair
3D Structure (crystal)TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea University of Science and Technology (UST)
Curated by ChEMBL
Korea University of Science and Technology (UST)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]-diprenorphine binding to kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]-diprenorphine binding to kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminus peptide (DYKDDDD)-tagged HER4 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 60 mins...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of C-terminus flag-tagged MEK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged MEK5 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human N-terminus peptide (DYKDDDD)-tagged HER2 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 6...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of N-terminus flag-tagged c-MET expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged VEGRF1 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged VEGRF2 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FGFR1 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FGFR3 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PDGFRalpha expressed in baculovirus infected insect cells using ATP as substrate after 30 minsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PDGFRbeta expressed in baculovirus infected insect cells using ATP as substrate after 60 minsMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TIE2 expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged c-kit expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged IGF-1R expressed in baculovirus infected insect cells using ATP as substrate after 20 minsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged Src expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of N-terminus flag-tagged Lck expressed in baculovirus infected insect cells using ATP as substrate after 20 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged CSK expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged FAK expressed in baculovirus infected insect cells using ATP as substrate after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged LynA expressed in baculovirus infected insect cells using ATP as substrate after 10 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged ASK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 2 group C member 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TAK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminus flag-tagged MEKK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintilla...More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminus flag-tagged IKK-beta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged JNK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged ERK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged p38alpha expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PKCtheta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scinti...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged GSK3-beta expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scint...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged B-raf expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintilla...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged TTK expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillati...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus flag-tagged PLK1 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea University of Science and Technology (UST)
Curated by ChEMBL
Korea University of Science and Technology (UST)
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human wild type EGFR expressed in Sf9 cells using [gamma32P]-ATP after 10 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea University of Science and Technology (UST)
Curated by ChEMBL
Korea University of Science and Technology (UST)
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminus 6XHis-tagged Aurora-B expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scint...More data for this Ligand-Target Pair