null
SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2
InChI Key InChIKey=VXBAJLGYBMTJCY-NSCUHMNNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50363196
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant JAK2 using Z'LYTETry6 peptide substrate after 1 hr by microplate readerMore data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 30 mins by LC-MS/MS analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assayChecked by AuthorMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
S BIO Pte. Ltd.
Curated by ChEMBL
S BIO Pte. Ltd.
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of CDK2 in human MV411 cells assessed as Rb phosphorylation after 24 hrs by Western blot analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 5 mins by LC-MS/MS analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using ethoxyresorufin as substrate after 5 mins by LC-MS/MS analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using Tolbutamide as substrate after 60 mins by LC-MS/MS analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 60 mins by LC-MS/MS analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human GST-tagged CDK9More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK3/N-terminal GST-tagged cyclin E expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of human recombinant GST-tagged JAK2 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human GST-tagged CDK5More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus infected Sf21 in...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant GST-tagged CDK2/cyclin E1More data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged full length CDK7/untagged recombinant full length human Cyclin H/N-terminal GST-tagged recombi...More data for this Ligand-Target Pair
TargetCyclin-K(Homo sapiens (Human))
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin K expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant full-length His-tagged CDK1/cyclin B1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant full-length GST/His-tagged CDK5/p25 expressed in baculovirus expression system by Z'-Lyte assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human CDK6More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full-length C-terminal His6-tagged CDK3/full-length human N-terminal GST-tagged Cyclin E expressed in baculovirus inf...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of C-terminal His6-tagged human CDK3/N-terminal GST-tagged human cyclin EMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human CDK5More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK9More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
S BIO Pte. Ltd.
Curated by ChEMBL
S BIO Pte. Ltd.
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant FLT3 after 1 hr by LanthaScreen assay platformMore data for this Ligand-Target Pair