null
SMILES CCn1c(nc2cncc(C(=O)N3CC[C@H](N)C3)c12)-c1nonc1N
InChI Key InChIKey=PHWHNHYZZNJPLB-QMMMGPOBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50365218
Affinity DataIC50: 1.64E+3nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLKMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 14nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair