null
SMILES CN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12
InChI Key InChIKey=JZNXLPPJRFFECJ-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50373071
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 3.81nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of TNFR1 binding to human TNFalpha expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 1.30E+4nMAssay Description:Binding affinity to TNFMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 1.18E+4nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % MeOH as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 9.77E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % MeOH as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 8.30E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % MeOH as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 6.18E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 5.36E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 8.44E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % PEG3350 as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 5.75E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 7.51E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMF as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 7.34E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 5.70E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 5.36E+3nMpH: 6.5Assay Description:Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR2 extracellular domain preincubated for 1...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR1 extracellular domain preincubated for 1...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of TNF-alpha (unknown origin) binding to TNFR1 by ELISAMore data for this Ligand-Target Pair
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School of Medicine
Curated by ChEMBL
Shanghai Jiaotong University School of Medicine
Curated by ChEMBL
Affinity DataKd: 1.38E+4nMAssay Description:Binding affinity to human RANKL measured after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
The Second People's Hospital of Fujian Provinc
Curated by ChEMBL
Affinity DataKd: 9.17E+4nMAssay Description:Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by MST assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School of Medicine
Curated by ChEMBL
Shanghai Jiaotong University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells assessed as reduction in RANKL/M-CSF-induced TRAP acti...More data for this Ligand-Target Pair
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Shanghai Jiaotong University School of Medicine
Curated by ChEMBL
Shanghai Jiaotong University School of Medicine
Curated by ChEMBL
Affinity DataKd: 1.38E+4nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Instituto de Salud Hospital Universitario La Paz - IdiPAZ
Curated by ChEMBL
Instituto de Salud Hospital Universitario La Paz - IdiPAZ
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of TNFR1 (unknown origin)More data for this Ligand-Target Pair