null
SMILES CC1=C[C@H]2C[C@@H](C1)c1c(C2)nc2cc(Cl)ccc2c1N
InChI Key InChIKey=UKCBMHDZLYYTMI-WDEREUQCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50379273
TargetAcetylcholinesterase(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 0.430nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and
(+)-(Ib) was evaluated spectrophotometrically at 25° C. by the
method of Ellma...More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 222nMpH: 8.0 T: 2°CAssay Description:BChE inhibitory activity determinations were carried out similarly by
the method of Ellman et al., using 0.02 unit/mL of human serum BChE and
300 u...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:β-Secretase (BACE-1, Sigma) inhibition studies were performed
by employing a peptide mimicking APP sequence as substrate
(methoxycoumarin-Ser-...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 0.0600nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and
(+)-(Ib) was evaluated spectrophotometrically at 25° C. by the
method of Ellma...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 0.740nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 222nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
TargetAcetylcholinesterase(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
UNIVERSITAT DE BARCELONA; PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
US Patent
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant BACE1 using methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl as substrate preincubated for 1 hr ...More data for this Ligand-Target Pair