null

SMILES CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(cc1C(=O)N1Cc2ccccc2C[C@H]1CO)C(=O)NS(=O)(=O)c1ccc2ccccc2c1

InChI Key InChIKey=XCELGEHXWSGXLN-XIFFEERXSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50384355   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM50384355(CHEMBL2031024 | US9346795, 91)copy SMILEScopy InChI
Affinity DataIC50: 50nMT: 2°CAssay Description:The assays were performed in black flat-bottom 384-well plates. The final assay volume was 50 μl prepared from additions of Gst-Bcl-2 (Bcl-2: GE...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2V27US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50384355(CHEMBL2031024 | US9346795, 91)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of Bcl-XL using fluoresceinated 18-mer Bim as substrate after 60 mins by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20866BMPubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM50384355(CHEMBL2031024 | US9346795, 91)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition in GST-tagged Bcl2 using [FAM]-IWIAQELRRIGDEFNAYY-NH2 as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20866BMPubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50384355(CHEMBL2031024 | US9346795, 91)copy SMILEScopy InChI
Affinity DataIC50: 6.27nMT: 2°CAssay Description:The assays were performed in black flat-bottom 384-well plates. The final assay volume was 55 μl prepared from additions of Biotin-Bcl-xL (Bcl-x...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2V27US Patent