null

SMILES Cc1nc(c[nH]1)-c1ccc(C)c(NC(=O)c2ccc(OCc3ccccn3)cc2)c1

InChI Key InChIKey=VHCKBVYAKAYQCA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50388709   

TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388709(CHEMBL2059867)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XCGPubMed
TargetSmoothened homolog(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388709(CHEMBL2059867)copy SMILEScopy InChI
Affinity DataEC50:  6.70nMAssay Description:Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentia...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388709(CHEMBL2059867)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XCGPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388709(CHEMBL2059867)copy SMILEScopy InChI
Affinity DataEC50:  7nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XCGPubMed