null

SMILES CNC(=O)c1nc(cnc1N)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1cccc(F)c1C

InChI Key InChIKey=LFOKRWIYRIYGNF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50393329   

LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN0B47PubMed
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human PI3Kbeta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 415nMAssay Description:Inhibition of human PI3Kdelta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CDC7More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of CRAF1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetInsulin receptor(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Platelet-derived growth factor subunit BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 805nMAssay Description:Inhibition of human PI3Kgamma expressed in C5a-stimulated mouse RAW 264.7 cells assessed as inhibition of AKT phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetAurora kinase B(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Aurora kinase BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CDK1/CyclinBMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed
LigandPNGBDBM50393329(CHEMBL2152253)copy SMILEScopy InChI
Affinity DataIC50: 342nMAssay Description:Inhibition of human PI3Kalpha expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S9NPubMed