null
SMILES CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1
InChI Key InChIKey=JZWXMCPARMXZQV-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 50398716
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataKi: 1.25E+3nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataKi: 7.57E+3nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged recombinant human HDAC4 (627 to 1084 residues) expressed in Baculovirus infected insect cel...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataKi: 1.28E+4nMAssay Description:Inhibition of C-terminal His-fusion tagged/N-terminal Strep-2 tagged recombinant human HDAC8 (1 to 377 residues) expressed in insect cells using Boc-...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 3.02E+3nMpH: 8.0Assay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMpH: 8.0Assay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
University of Illinois at Chicago
Curated by ChEMBL
University of Illinois at Chicago
Curated by ChEMBL
Affinity DataIC50: 5.14E+3nMAssay Description:Inhibition of HDAC11More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
University of Illinois at Chicago
Curated by ChEMBL
University of Illinois at Chicago
Curated by ChEMBL
Affinity DataIC50: 7.57E+3nMAssay Description:Inhibition of HDAC10More data for this Ligand-Target Pair
Affinity DataIC50: 6.72E+3nMAssay Description:Inhibition of HDAC9More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 4.46E+3nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 9.39E+3nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
Affinity DataIC50: 6.68E+3nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 3.02E+3nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 3.02E+3nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 3.02E+3nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.02nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of HDAC6 (unknown origin) preincubated for 10 mins followed by Ac-Leu-GlyLys(Ac)-AMC substrate addition measured after 30 mins by fluoresc...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human N-terminal tagged human HDAC6 expressed in HEK293T/17 using Ac-Gly-Ala-[Ac-Lys]-AMC as substrate preincubated for 10 mins followe...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
University of Illinois at Chicago
Curated by ChEMBL
University of Illinois at Chicago
Curated by ChEMBL
Affinity DataIC50: 501nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
University of Illinois at Chicago
Curated by ChEMBL
University of Illinois at Chicago
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells u...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T/17 cells using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of recombinant human HDAC7 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant human HDAC8 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human HDAC9 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
University of Illinois at Chicago
Curated by ChEMBL
University of Illinois at Chicago
Curated by ChEMBL
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of recombinant human HDAC11 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of recombinant human HDAC4 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human HDAC6 expressed in HEK293T/17 cells using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to...More data for this Ligand-Target Pair
Affinity DataIC50: 6.62E+3nMAssay Description:Inhibition of recombinant human HDAC5 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant HDAC1 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HDAC6 expressed in HEK293/T17 cells using pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.; Board of Trustees of the University of Illinois
US Patent
Affinity DataIC50: 151nMAssay Description:Inhibition of human HDAC1 expressed in HEK293/T17 cells pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 276nMAssay Description:Inhibition of human HDAC2 expressed in HEK293/T17 cells pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human HDAC3 expressed in HEK293/T17 cells pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of human HDAC4 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: 6.62E+3nMAssay Description:Inhibition of human HDAC5 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of human HDAC7 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Heinrich-Heine-University D£sseldorf
Curated by ChEMBL
Affinity DataIC50: 988nMAssay Description:Inhibition of human HDAC8 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human HDAC9 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair