null

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1

InChI Key InChIKey=QPOURHROVVCOHC-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 50399676   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0SNGUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataKd:  0.600nMAssay Description:Binding affinity to wild type EGFR by KINOMEscan kinase binding assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in ERK phosphorylation incubated for 8 hrs by Western blotting methodMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in AKT phosphorylation incubated for 8 hrs by Western blotting methodMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant PKCalpha by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant EGFR by radiometric kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant p38gamma by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant p38alpha by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetSerine/threonine-protein kinase WNK1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant WNK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant VEGFR2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant TYK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant ROCK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PLK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PKN2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human recombinant PKN1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant PKCtheta by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PKBalpha by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PIM2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human recombinant MNK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant MNK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MK5 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant JNK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human recombinant JAK3 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant JAK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant JAK1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IRAK4 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GSK3beta by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant ERK2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetCOUP transcription factor 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant COT1 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 720nMAssay Description:Inhibition of human recombinant SYK by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant SRC by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MST1R by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human recombinant MET by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant KIT by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetInsulin receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant INSR by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IGF1R by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant ERBB4 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant ERBB2 by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant EGFR by radiometric kinase assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant ALK by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KBVPubMed
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent
LigandPNGBDBM50399676(CHEMBL2178352 | US9096601, 8-26)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair