null

SMILES Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1

InChI Key InChIKey=YGWURLOZYUXZKA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50401549   

TargetC-C chemokine receptor type 2(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Binding affinity to human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKi:  79.4nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKi:  398nMAssay Description:Binding affinity to CCR1 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKi:  398nMAssay Description:Binding affinity to CCR4 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetC-C chemokine receptor type 2(Mus musculus)
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to murine CCR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataKd:  1.00E+4nMAssay Description:Antagonist activity at CCR2 in human whole blood assessed as inhibition of CCL2-stimulated monocyte shape changeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataIC50: 631nMAssay Description:Inhibition of cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BZJPubMed