null
SMILES CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
InChI Key InChIKey=BJEMSIVBBUBXMZ-JTQLQIEISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50416603
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataKi: 5.70nMAssay Description:Displacement of [3H]-A-804598 from human P2X7 receptor expressed in HEK293 cell membrane by in vitro binding assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataKi: 68nMAssay Description:Displacement of [3H]-A804598 from human P2X7 expressed in human HEK293 cell membrane incubated for 1 hr by microplate scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 510nMAssay Description:Displacement of [3H]-A-804598 from rat P2X7 receptor expressed in HEK293 cell membrane by in vitro binding assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counti...More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 332nMAssay Description:Displacement of [3H]-A804598 from human P2X7 expressed in human HEK293 cell membrane incubated for 1 hr by microplate scintillation counting methodMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 119nMAssay Description:Inhibition of human P2X7 expressed in human HEK293 cells assessed as reduction in BzATP-stimulated TO-PRO-3 incorporation preincubated with compound ...More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by F...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by FLI...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by F...More data for this Ligand-Target Pair
Affinity DataIC50: 251nMAssay Description:Antagonist activity at rat recombinant P2X7 receptorMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.16nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.16nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 316nMAssay Description:Inhibition of rat P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair