null

SMILES CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(O)cc12

InChI Key InChIKey=FJHBVJOVLFPMQE-QFIPXVFZSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50418088   

TargetCytochrome P450 3A4(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)copy SMILEScopy InChI
Affinity DataKi:  2.60E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ33X3PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)copy SMILEScopy InChI
Affinity DataIC50: 176nMAssay Description:TP_TRANSPORTER: drug resistance(Imatinib mesylate) in BCRP-expressing SaoS2 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human topoisomerase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028W6SPubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+5nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC343RPubMed