null

SMILES CN1CCN(CC1)S(=O)(=O)c1ccc2NC(=O)C(=C(c3nc4ccccc4[nH]3)c3ccccc3)c2c1

InChI Key InChIKey=QBVSDKQSKUMRFT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50421022   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421022(CHEMBL2086748)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of N-terminal GST-tagged KDR after 4 hrs by luciferase-luciferin coupled chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421022(CHEMBL2086748)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421022(CHEMBL2086748)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of FGFR1 in human SK-N-MC cells assessed as inhibition of FGF-induced ERK phosphorylation incubated for 1 hr prior to VEGF-stimulation mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421022(CHEMBL2086748)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha after 2 hrs by luciferase-luciferin coupled chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421022(CHEMBL2086748)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of KDR in human HUVEC cells assessed as inhibition of VEGF-induced ERK phosphorylation incubated for 1 hr prior to VEGF-stimulation measur...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421022(CHEMBL2086748)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of N-terminal GST-tagged FGFR1 using poly(Glu,Tyr) as substrate after 30 mins by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed