null

SMILES CCN1CCC(CC1)Nc1ccc2NC(=O)C(=C(c3nc4ccccc4[nH]3)c3ccc(C)cc3)c2c1

InChI Key InChIKey=ACSSIWPJCYCXGD-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50421032   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421032(CHEMBL2086754)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of FGFR1 in human SK-N-MC cells assessed as inhibition of FGF-induced ERK phosphorylation incubated for 1 hr prior to VEGF-stimulation mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421032(CHEMBL2086754)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421032(CHEMBL2086754)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal GST-tagged KDR after 4 hrs by luciferase-luciferin coupled chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421032(CHEMBL2086754)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged FGFR1 using poly(Glu,Tyr) as substrate after 30 mins by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421032(CHEMBL2086754)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha after 2 hrs by luciferase-luciferin coupled chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50421032(CHEMBL2086754)copy SMILEScopy InChI
Affinity DataIC50: 112nMAssay Description:Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9SD4PubMed