null

SMILES [#8]-[#6](=O)-[#6]-1=[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]\[#7]=[#6](\c2ccccc2)-c2ccccc2)-[#6]-1

InChI Key InChIKey=NGNALWDRPKNJGR-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50426075   

TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MF4PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MF4PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MF4PubMed
TargetSodium- and chloride-dependent betaine transporter(Mus musculus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of mouse BGT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69MF4PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University at Munich

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ38HVPubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 148nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2MJJPubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of GAT-1 in rat brain homogenate assessed as decrease in [3H]GABA uptake preincubated for 8 mins followed by [3H]GABA addition and measure...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P272J5PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 8.51E+5nMAssay Description:Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2MJJPubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2MJJPubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2MJJPubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Universit£ catholique de Louvain

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)copy SMILEScopy InChI
Affinity DataKd:  27nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD227RPubMed