null

SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1

InChI Key InChIKey=BYTKNUOMWLJVNQ-UHFFFAOYSA-N

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50427453   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 241nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WZ1US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))TBA
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
In DepthDetails
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WZ1US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 214nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WZ1US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 960nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WZ1US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WZ1US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DR9PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 289nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DR9PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DR9PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DR9PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 960nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DR9PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 214nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DR9PubMed
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Pfizer

LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 241nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Pfizer

LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24170D7US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 214nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24170D7US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 960nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24170D7US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24170D7US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 34nMMore data for this Ligand-Target Pair
In DepthDetails
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 158nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 280nMMore data for this Ligand-Target Pair
In DepthDetails
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
SignalRx Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)copy SMILEScopy InChI
Affinity DataIC50: 1.55E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WZ1US Patent