null

SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@H]4CC[C@H](O)CC4)c3c2n1

InChI Key InChIKey=RUSWLTDNJLODMQ-SHTZXODSSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50428118   

LigandPNGBDBM50428118(CHEMBL2331659 | US8791131, 134)copy SMILEScopy InChI
Affinity DataKi:  0.5nM ΔG°:  -12.7kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5XV8US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50428118(CHEMBL2331659 | US8791131, 134)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1F0BPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50428118(CHEMBL2331659 | US8791131, 134)copy SMILEScopy InChI
Affinity DataKi:  2nM ΔG°:  -11.9kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5XV8US Patent