null

SMILES Clc1cccc2c(ccnc12)C(=O)NCC(=O)N1CCC[C@H]1C#N

InChI Key InChIKey=GVEVKFYZSMHFEB-NSHDSACASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50434162   

TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
Universiteit Antwerp; Fox Chase Cancer Center

US Patent
LigandPNGBDBM50434162(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)copy SMILEScopy InChI
Affinity DataIC50: 190nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37V6DUS Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Universiteit Antwerp; Fox Chase Cancer Center

US Patent
LigandPNGBDBM50434162(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37V6DUS Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Universiteit Antwerp; Fox Chase Cancer Center

US Patent
LigandPNGBDBM50434162(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37V6DUS Patent
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
Universiteit Antwerp; Fox Chase Cancer Center

US Patent
LigandPNGBDBM50434162(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP83J7PubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Universiteit Antwerp; Fox Chase Cancer Center

US Patent
LigandPNGBDBM50434162(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)copy SMILEScopy InChI
Affinity DataIC50: 350nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37V6DUS Patent
TargetProlyl endopeptidase(Homo sapiens (Human))
Universiteit Antwerp; Fox Chase Cancer Center

US Patent
LigandPNGBDBM50434162(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP83J7PubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Universiteit Antwerp; Fox Chase Cancer Center

US Patent
LigandPNGBDBM50434162(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37V6DUS Patent