null

SMILES COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(O)=O

InChI Key InChIKey=TVTXCJFHQKSQQM-LJQIRTBHSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50437206   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50437206(CHEMBL2402737)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WMKPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50437206(CHEMBL2402737)copy SMILEScopy InChI
Affinity DataKd:  0.150nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M960ZPubMed
TargetProtein Mdm4(Homo sapiens (Human))TBA
LigandPNGBDBM50437206(CHEMBL2402737)copy SMILEScopy InChI
Affinity DataKd: <100nMAssay Description:Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaMore data for this Ligand-Target Pair
In DepthDetails
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50437206(CHEMBL2402737)copy SMILEScopy InChI
Affinity DataKd:  9.80nMAssay Description:Binding affinity to HDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D1VPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50437206(CHEMBL2402737)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6G6HPubMed