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SMILES COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1

InChI Key InChIKey=QVXUHZBHADDLFR-GOSISDBHSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50437408   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM50437408(CHEMBL2408790 | US9023865, 2)copy SMILEScopy InChI
Affinity DataIC50: 0.286nMAssay Description:Inhibition of human ERK2 pre-incubation for 15 mins before substrate addition measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862HWSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM50437408(CHEMBL2408790 | US9023865, 2)copy SMILEScopy InChI
Affinity DataIC50: 0.286nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94CCUS Patent
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM50437408(CHEMBL2408790 | US9023865, 2)copy SMILEScopy InChI
Affinity DataIC50: 0.152nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94CCUS Patent