null

SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c2oc(cc12)-c1ccccc1C#N

InChI Key InChIKey=XCKISTZRDFIEIS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50438196   

TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
OSI Pharmaceuticals LLC

Curated by ChEMBL

LigandBDBM50438196(CHEMBL2407781)copy SMILEScopy InChI

Affinity DataIC50: 560nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5J2KPubMed

TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
OSI Pharmaceuticals LLC

Curated by ChEMBL

LigandBDBM50438196(CHEMBL2407781)copy SMILEScopy InChI

Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5J2KPubMed