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SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1c(F)cccc1Cl

InChI Key InChIKey=BXKLAYQKTVKJCY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50444038   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
JANSSEN PHARMACEUTICA NV

US Patent
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 7.8 T: 2°CAssay Description:Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z60M6HUS Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
JANSSEN PHARMACEUTICA NV

US Patent
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)copy SMILEScopy InChI
Affinity DataIC50: 14nMpH: 7.8 T: 2°CAssay Description:Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z60M6HUS Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
JANSSEN PHARMACEUTICA NV

US Patent
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assayMore data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
JANSSEN PHARMACEUTICA NV

US Patent
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsMore data for this Ligand-Target Pair
In DepthDetails
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
JANSSEN PHARMACEUTICA NV

US Patent
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant rat PDE10A expressed in baculovirus infected insect SF9 cells using [3H]-cAMP as substrate after 60 mins by scintillation p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20CQPubMed