null
SMILES ONC(=O)C1c2ccccc2-c2ccccc12
InChI Key InChIKey=LEYJMVDNPXDXSO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50446482
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measure...More data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substra...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of recombinant human HDAC6 expressed in HEK293 cells using Lys-Ac-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence as...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Affinity DataIC50: 3.89E+4nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substr...More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Charles River Discovery (previously BioFocus)
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human C-terminal His-tagged HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using Boc-...More data for this Ligand-Target Pair