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SMILES [H][C@@]12CN(C[C@]1([H])CN(C2)c1nc(Nc2cnn(C)c2)c2ncn(C(C)C)c2n1)C(=O)C=C

InChI Key InChIKey=VLUFVWDZAMAWPX-GASCZTMLSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50450879   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM50450879(CHEMBL4207951)copy SMILEScopy InChI
Affinity DataKi:  85nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2CJZPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM50450879(CHEMBL4207951)copy SMILEScopy InChI
Affinity DataIC50: 805nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2CJZPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM50450879(CHEMBL4207951)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2CJZPubMed