null
SMILES CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1
InChI Key InChIKey=ADZBMFGQQWPHMJ-RHSMWYFYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50460035
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University of Sharjah
Curated by ChEMBL
University of Sharjah
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University of Sharjah
Curated by ChEMBL
University of Sharjah
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University of Sharjah
Curated by ChEMBL
University of Sharjah
Curated by ChEMBL
Affinity DataKd: 3.40nMAssay Description:Binding affinity to human wild type CSF1R (I564 to S939 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: 8.70E+3nMAssay Description:Binding affinity to human wild type FLT3 (V592 to Y969 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University of Sharjah
Curated by ChEMBL
University of Sharjah
Curated by ChEMBL
In DepthDetails
Affinity DataIC50: 579nMAssay Description:Inhibition of human PDGFRbeta phosphorylation in PDGF-DD induced human HEK293-TetR cells incubated for 1 hr followed by PDGF-DD stimulation and measu...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University of Sharjah
Curated by ChEMBL
University of Sharjah
Curated by ChEMBL
Affinity DataIC50: 155nMAssay Description:Inhibition of CSF1R phosphorylation in M-CSF induced human THP1 cells incubated for 30 mins by ELISA assayMore data for this Ligand-Target Pair
Affinity DataKd: 46nMAssay Description:Binding affinity to human wild type PDGFRbeta (V582 to Y1009 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding affinity to human wild type PDGFRalpha (V575 to D1002 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.00E+3nMAssay Description:Binding affinity to c-Kit (unknown origin) by kinome scan assayMore data for this Ligand-Target Pair