null
SMILES NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2
InChI Key InChIKey=DREIJXJRTLTGJC-UHFFFAOYSA-N
PDB links: 4 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50463838
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 catalytic domain (826 to 1132 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
3D Structure (crystal)TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TYK2 catalytic domain (871 to 1187 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK1 catalytic domain (850 to 1154 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL-2-induced T cell proliferation after 3 days by alamar blue assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 catalytic domain (826 to 1132 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK1 catalytic domain (850 to 1154 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Affinity DataIC50: 0.710nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 catalytic domain (795 to 1124 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 catalytic domain (795 to 1124 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human JAK1 kinase-domain using Biotin-Lyn-Substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase-domain using Biotin-Lyn-Substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human TYK2 kinase domain using biotin-IRS1-substrate as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human JAK3 kinase-domain using Biotin-Lyn-Substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human JAK1 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK3 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human Tyk2 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 248nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as reduction in EPO-induced cell proliferation after 2 days by alamar blue assayMore data for this Ligand-Target Pair