null
SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(Cl)cn12
InChI Key InChIKey=KFMPJPLODWMESO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50465468
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 Y1537A mutant expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 6.13E+3nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 R1605A mutant expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.07E+4nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 R1608A mutant expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 7.33E+3nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 R1602A mutant expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed ...More data for this Ligand-Target Pair