null
SMILES [H][C@@]12CC[C@@]([H])(N1C(=O)CNC(C)=O)c1cc(Nc3ncc(c(NC4CCC4)n3)C(F)(F)F)ccc21
InChI Key InChIKey=RYYNGWLOYLRZLK-RBUKOAKNSA-N
PDB links: 3 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50466804
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length His-tagged recombinant aurora B (unknown origin) expressed in insect cells using biotinylated LRRWSLG substrate by scintill...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of aurora A in human MDA-MB-231 cells assessed as reduction in enzyme autophosphorylation incubated for 4 hrs by high-content immunofluore...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full-length His-tagged recombinant aurora A (unknown origin) expressed in insect cells using biotinylated LRRWSLG substrate by Z'-LYTE ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant full-length His-tagged Aurora B (unknown origin) expressed in insect cells using biotinylated LRRWSLG as substrate measured...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of aurora B in human MDA-MB-231 cells assessed as reduction in phosphorylation of histone H3 on Ser10 incubated for 4 hrs by high-content ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant full-length His-tagged Aurora A (unknown origin) expressed in insect cells using biotinylated LRRWSLG as substrate in prese...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of aurora B in human MDA-MB-231 cells assessed as reduction in enzyme autophosphorylation incubated for 4 hrs by high-content immunofluore...More data for this Ligand-Target Pair