null
SMILES Cc1c(oc2ccc(C)cc12)-c1n(nc2c1c(N)n[nH]c2=O)-c1ccc(NC(=O)C=C)cc1
InChI Key InChIKey=HKMTYQNMRIBAHX-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50504104
Affinity DataKi: 1.90nMAssay Description:Irreversible inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human EGFR using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERbb4 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ABL using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human FGFR3 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PDGFRbeta using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human c-Src using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ALK using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human VEGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FGFR2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human FGFR4 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
3D Structure (crystal)TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERbb2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human c-MET using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human EPHA2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISA relative to controlMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human VEGFR2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair