null

SMILES CC(C)(O)Cn1c2ccccc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1ccccc1

InChI Key InChIKey=UDMIRQWCOXFLHS-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50505836   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH & Co KG

Curated by ChEMBL
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant GST-tagged wild type EGFR expressed in baculovirus expression system assessed as decrease in phosphorylation of ULigh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD14ZQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH & Co KG

Curated by ChEMBL
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)copy SMILEScopy InChI
Affinity DataIC50: 267nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD14ZQPubMed
TargetEpidermal growth factor receptor(Mus musculus)
Boehringer Ingelheim RCV GmbH & Co KG

Curated by ChEMBL
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD14ZQPubMed
TargetEpidermal growth factor receptor [695-1022](Homo sapiens (Human))TBA
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP56F9US Patent
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)copy SMILEScopy InChI
Affinity DataIC50: 267nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP56F9US Patent
TargetEpidermal growth factor receptor [695-1022](Homo sapiens (Human))TBA
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP56F9US Patent
LigandPNGBDBM50505836(CHEMBL4434788 | US11174245, # I-064)copy SMILEScopy InChI
Affinity DataIC50: 13.1nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MP56F9US Patent