null

SMILES Cc1nnc(o1)N1CCC(CC1)C(=O)N1N=CC[C@H]1c1cc(F)cc(F)c1

InChI Key InChIKey=XNZJMXBRWHMCOG-INIZCTEOSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50512997   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50512997(CHEMBL4545939)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necroptosis measured after 24 hrs by cell titer-glo luminesc...More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JFTPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50512997(CHEMBL4545939)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNF/zVAD.fmk-induced necrotic death measured after 24 hrs by cell titer-glo luminesce...More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JFTPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50512997(CHEMBL4545939)copy SMILEScopy InChI
Affinity DataIC50: 8.5nMAssay Description:Inhibition of RIP1 in human whole blood assessed as reduction in TNFalpha/zVAD-fmk/SMAC-induced MIP1alpha production measured after 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JFTPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50512997(CHEMBL4545939)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m...More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JFTPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50512997(CHEMBL4545939)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16...More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JFTPubMed