null

SMILES CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCCC1

InChI Key InChIKey=XNKBJGBUELOBBG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514920   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50514920(CHEMBL4459509 | US10988478, Example 214)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC1419PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50514920(CHEMBL4459509 | US10988478, Example 214)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K077DTUS Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50514920(CHEMBL4459509 | US10988478, Example 214)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC1419PubMed