null

SMILES COc1cccc(c1)N1CCN(CC1)c1nc2CCSCc2c(=O)[nH]1

InChI Key InChIKey=HKHWXFAGFIXRIT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50522342   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
RIKEN

Curated by ChEMBL
LigandPNGBDBM50522342(CHEMBL4538780)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46WC3PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
RIKEN

Curated by ChEMBL
LigandPNGBDBM50522342(CHEMBL4538780)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46WC3PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
RIKEN

Curated by ChEMBL
LigandPNGBDBM50522342(CHEMBL4538780)copy SMILEScopy InChI
Affinity DataIC50: 148nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46WC3PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
RIKEN

Curated by ChEMBL
LigandPNGBDBM50522342(CHEMBL4538780)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46WC3PubMed