null
SMILES COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC
InChI Key InChIKey=AUOSKLDNVNGKRR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50524284
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 5.10E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged STK16 (unknown origin) (13 to 305 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 5.30E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged AAK1 (unknown origin) (31 to 396 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to C-terminal AVI-tagged BMP2K (unknown origin) (38 to 345 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetAtypical kinase COQ8A, mitochondrial(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 190nMAssay Description:Binding affinity to biotinylated full length human ADCK3 expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 110nMAssay Description:Binding affinity to biotinylated human RIPK2 (1 to 310 residues) expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent ...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Displacement of fluorescent tracer from N-terminus of human RIPK2 expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 4.5nMAssay Description:Binding affinity to GAK (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase NLK(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 520nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of NanoBRET tracer 5 binding to NL-fused GAK (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 4.10nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
Affinity DataKd: 1.20E+3nMAssay Description:Binding affinity to human wild type partial length non-phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system by Kinome...More data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to human wild type partial length ACVR1 (C188 to C509 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetAtypical kinase COQ8A, mitochondrial(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 260nMAssay Description:Binding affinity to human wild type full-length ADCK3 expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 710nMAssay Description:Binding affinity to human wild type partial length EphB6 (Q634 to P948 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase NLK(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 520nMAssay Description:Binding affinity to wild-type human full length NLK expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 110nMAssay Description:Binding affinity to wild-type human partial length RIPK2 (M1 to K310 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of GAK (unknown origin) by in-cell pulse based assayMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 1.90nMAssay Description:Binding affinity to biotinylated human GAK (13 to 338 residues) expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent T...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Displacement of fluorescent tracer from N-terminus of human GAK expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair