null

SMILES [#6]-[#8]-c1ccc(cc1)S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/C#Cc1cccc(-[#6])n1

InChI Key InChIKey=ZMSMHRWTKJCWBW-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50529978   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 using 3-cyano-7-ethoxycoumarin as substrate preincubated for 10 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 using 3-cyano-7-ethoxycoumarin as substrate preincubated for 10 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50529978(CHEMBL4592284)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171JFPubMed