null

SMILES CC[C@H](C(O)=O)c1ccc2cc(OC)ccc2c1

InChI Key InChIKey=LSDAHSHHKKHOKE-AWEZNQCLSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50533568   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z47WNPubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z47WNPubMed
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of human recombinant AKR1C2 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z47WNPubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 4.81E+4nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 1.93E+3nMAssay Description:The effect of the compounds on COX-1 activity was determined by a continuous colorimetric assay that monitored the oxidation of N, N, N, N-tetramethy...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The effect of the compounds on COX-1 activity was determined by a continuous colorimetric assay that monitored the oxidation of N, N, N, N-tetramethy...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:The effect of the compounds on COX-1 activity was determined by a continuous colorimetric assay that monitored the oxidation of N, N, N, N-tetramethy...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The effect of the compounds on COX-1 activity was determined by a continuous colorimetric assay that monitored the oxidation of N, N, N, N-tetramethy...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50533568(CHEMBL4466610 | US11459295, Compound LM5750B 8a)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0Z58US Patent