null

SMILES O=C(Nc1c2CCCc2cc2CCCc12)NS(=O)(=NC#N)c1ccccn1

InChI Key InChIKey=GDAHMFIDUIIGMC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50538421   

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare Ltd.

Curated by ChEMBL
LigandPNGBDBM50538421(CHEMBL4649141 | US11236045, Example 30)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WP2PubMed
TargetUromodulin(Human)TBA
LigandPNGBDBM50538421(CHEMBL4649141 | US11236045, Example 30)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:THP1 (Tamm-Horsfall Protein 1) monocytes were differentiated with PMA (Phorbol 12-myristate 13-acetate) (100 ng/ml) and incubated at 37° C. for 20 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K4FDJUS Patent
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare Ltd.

Curated by ChEMBL
LigandPNGBDBM50538421(CHEMBL4649141 | US11236045, Example 30)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in TNF alpha level preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WP2PubMed