null

SMILES OC(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.CN(C)c1ccc(\C=C\C=C\c2cc(C)[n+](CCCCCc3c[nH]cn3)c(C)c2)cc1

InChI Key InChIKey=JECYYTFAWYJNHN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50538678   

TargetHistamine H3 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H3R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKi:  1.82E+3nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human recombinant H2R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKi: <4.79E+3nMAssay Description:Displacement of [3H]pyrilamine from human recombinant H1R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKd:  0.970nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKd:  0.970nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H4 receptor(Mus musculus (mouse))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKd:  154nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKd:  78nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKd:  80nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H4 receptor(Mus musculus (mouse))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataKd:  162nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataEC50:  72nMAssay Description:Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)copy SMILEScopy InChI
Affinity DataEC50:  65nMAssay Description:Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HZ1PubMed