null

SMILES Nc1nccc2n([C@@H]3CCCN(C3)C(=O)C=C)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50557487   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50557487(Tolebrutinib)copy SMILES
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human BTK in human microglia cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5JNKPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50557487(Tolebrutinib)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of human BTK using fluorescein-labeled polyGAT peptide as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B641CPubMed
TargetEarly activation antigen CD69(Homo sapiens)TBA
LigandPNGBDBM50557487(Tolebrutinib)copy SMILES
Affinity DataIC50: 200nMAssay Description:Inhibition of CD69 in human whole blood preincubated for 30 mins followed by anti-human IgD stimulation and measured after 18 to 22 hrs by flow cytom...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B641CPubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))TBA
LigandPNGBDBM50557487(Tolebrutinib)copy SMILES
Affinity DataIC50: 7.80nMMore data for this Ligand-Target Pair
In DepthDetails
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50557487(Tolebrutinib)copy SMILES
Affinity DataIC50: 74nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50557487(Tolebrutinib)copy SMILES
Affinity DataKd:  1.40nMAssay Description:Binding affinity to wild-type human full length BTK (M1 to S659 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B641CPubMed