null

SMILES CN1CCC2(CCCN2C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc3c(N)ncnc23)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50561818   

LigandPNGBDBM50561818(CHEMBL4783377)copy SMILES
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR22Z5PubMed
LigandPNGBDBM50561818(CHEMBL4783377)copy SMILES
Affinity DataKd:  7.60nMAssay Description:Binding affinity to N-terminal FLAG-tagged human PRMT5 (1 to 637 residues)/N-terminal thrombin His-tagged MEP50 (2 to 342 residues) expressed in bacu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR22Z5PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50561818(CHEMBL4783377)copy SMILES
Affinity DataIC50: 200nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR22Z5PubMed