null
SMILES C[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCCOCc1cn(CCOc2ccc(cc2)N(Cc2cccc(O)c2Cl)CC2(CCCC2)c2ccccc2F)nn1)C(C)(C)C)c1ccc(cc1)-c1scnc1C
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50574417
Affinity DataIC50: 53nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 419nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Antagonist activity at ERalpha in human MCF7 cells assessed as reduction in PGR gene expression incubated for 24 hrs by qPCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 517nMAssay Description:Binding affinity to ERalpha D538G mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Affinity DataIC50: 203nMAssay Description:Binding affinity to ERalpha S463P mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair