null

SMILES CC[C@H](C)n1nc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50574994   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM50574994(CHEMBL4847620)copy SMILES
Affinity DataKd:  0.0693nMAssay Description:Inhibition of recombinant PRC2 complex (unknown origin) assessed as dissociation rate constant using H3K27me0 peptide substrate incubated for 3 hrs b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44V3JPubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM50574994(CHEMBL4847620)copy SMILES
Affinity DataIC50: 11nMAssay Description:Inhibition of EZH2 (unknown origin) using H3K27me0 peptide substrate incubated for 3 hrs by HMT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44V3JPubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM50574994(CHEMBL4847620)copy SMILES
Affinity DataKd:  21nMAssay Description:Inhibition of recombinant PRC2 complex (unknown origin) assessed as kd/ka using H3K27me0 peptide substrate incubated for 3 hrs by HMT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44V3JPubMed