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SMILES CO[C@@H]1CCCN(C1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50577134   

TargetProteasome subunit beta type-8(Homo sapiens (Human))TBA
LigandPNGBDBM50577134(CHEMBL4877708)copy SMILES
Affinity DataIC50: 30nMAssay Description:Inhibition of human proteasome subunit beta-5i chymotrypsin like activity using SUC-ANW-AMC as flurogenic substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WZNPubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))TBA
LigandPNGBDBM50577134(CHEMBL4877708)copy SMILES
Affinity DataIC50: 244nMAssay Description:Inhibition of chymotrypsin-like activity of human 20s proteasome beta 5c subunit using suc-WLA-AMC as flurogenic substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WZNPubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))TBA
LigandPNGBDBM50577134(CHEMBL4877708)copy SMILES
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human trypsin-like activity of 20s proteasome beta 2i subunit using SUC-VGR-AMC as flurogenic substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WZNPubMed
TargetProteasome subunit beta type-9(Homo sapiens (Human))TBA
LigandPNGBDBM50577134(CHEMBL4877708)copy SMILES
Affinity DataIC50: 267nMAssay Description:Inhibition of human caspase-like activity of 20s proteasome beta 1i subunit using SUC-PAL-AMC as flurogenic substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WZNPubMed
TargetProteasome subunit beta type-4(Homo sapiens (Human))TBA
LigandPNGBDBM50577134(CHEMBL4877708)copy SMILES
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human trypsin-like activity of 20s proteasome beta 2c subunit using SUC-KQL-AMC as flurogenic substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WZNPubMed
TargetProteasome subunit alpha type-1(Homo sapiens (Human))TBA
LigandPNGBDBM50577134(CHEMBL4877708)copy SMILES
Affinity DataIC50: 3.80nMAssay Description:Inhibition of caspase-like activity of human proteasome beta-1c subunit using SUC-LLE-AMC as flurogenic substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WZNPubMed