null

SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@H]1c1cc(F)ccc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50577766   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50577766(CHEMBL4856292)copy SMILES
Affinity DataIC50: 3.40nMAssay Description:Inhibition of N-terminal GST-tagged human TRKA (436 to 790 residues) expressed in baculovirus infected Sf21 cells using TK as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26W9FXBPubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50577766(CHEMBL4856292)copy SMILES
Affinity DataIC50: 4.70nMAssay Description:Inhibition of N-terminal GST-tagged human TRKB (456 to 822 residues) expressed in baculovirus infected Sf21 cells using TK as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26W9FXBPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50577766(CHEMBL4856292)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-tagged human TRKC (456 to 825 residues) expressed in Sf21 using TK as substrate in presence of ATP measured after 40 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26W9FXBPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50577766(CHEMBL4856292)copy SMILES
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N01BKNPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50577766(CHEMBL4856292)copy SMILES
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N01BKNPubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50577766(CHEMBL4856292)copy SMILES
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N01BKNPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50577766(CHEMBL4856292)copy SMILES
Affinity DataIC50: 3.90nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z323JHPubMed