null

SMILES [H][C@]12Cc3ccccc3[C@]([H])([C@H](NC1=O)C(C)C)N2C(=O)c1cc(NC2CCN(CC(C)(C)F)CC2)c2nnc(C)n2n1

InChI Key

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50584925   

TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 6.30nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd:  1.30nMAssay Description:Binding affinity to ATAD2 bromodomain (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of Alexafluor 647-JQ1 from GST-BRD4 BD1 BD2 (44 to 460 residues) (unknown origin) incubated for 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 126nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 79nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 50nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 100nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-BRD4 BD1/BD2 (44 to 460 residues) (unknown origin) transfected in human HCT116 cells incubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetATPase family AAA domain-containing protein 2B(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd:  7.90nMAssay Description:Binding affinity to human ATAD2B bromodomain assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd:  126nMAssay Description:Binding affinity to human BRD2 bromodomain 1 assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd:  200nMAssay Description:Binding affinity to human BRD2 bromodomain 2 assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd:  200nMAssay Description:Binding affinity to human BRD3 bromodomain 2 assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <316nMAssay Description:Binding affinity to human BRD9 bromodomain by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd:  200nMAssay Description:Binding affinity to human BRDT bromodomain 1 assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <316nMAssay Description:Binding affinity to human CECR2 bromodomain assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <3.16E+3nMAssay Description:Binding affinity to human EP300 bromodomain assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <316nMAssay Description:Binding affinity to human FALZ bromodomain by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetProtein polybromo-1(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <316nMAssay Description:Binding affinity to human PBRM1 bromodomain 5 assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <316nMAssay Description:Binding affinity to human PCAF bromodomain assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetProbable global transcription activator SNF2L2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <3.16E+3nMAssay Description:Binding affinity to human SMARCA2 bromodomain assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd:  158nMAssay Description:Binding affinity to human TAF1 bromodomain 2 assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetBromodomain and WD repeat-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataKd: <316nMAssay Description:Binding affinity to human WDR9 bromodomain 2 assessed as dissociation constant by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280CH8PubMed
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50584925(CHEMBL5079885)copy SMILES
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB