null

SMILES CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2

InChI Key

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50585045   

TargetCalcium/calmodulin-dependent protein kinase type 1B(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 830nMAssay Description:Inhibition of CAMK1B (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataKd:  7.29E+3nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 354nMAssay Description:Inhibition of FLT3 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 87nMAssay Description:Inhibition of TNIK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 334nMAssay Description:Inhibition of MYLK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 13nMAssay Description:Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 19nMAssay Description:Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 173nMAssay Description:Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 477nMAssay Description:Inhibition of TRKA (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoMMDBKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 6.71E+3nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 2.08E+3nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 58nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 37nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 8.78E+3nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 1.81E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 188nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 514nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataKd:  0.912nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataKd:  35nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails

TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))TBA

LigandBDBM50585045(CHEMBL5093741)copy SMILES

Affinity DataIC50: 212nMAssay Description:Inhibition of SGK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BDBPubMed