BindingDB

null

SMILES CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2

InChI Key

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50585046

Serine/threonine-protein kinase Sgk1(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 690nMAssay Description:Inhibition of SGK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Glycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

Kd: 936nMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 5nMAssay Description:Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair

PDB
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Dual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 132nMAssay Description:Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Mitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.62E+3nMAssay Description:Inhibition of YSK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Ribosomal protein S6 kinase alpha-6(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 37nMAssay Description:Inhibition of RSK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Focal adhesion kinase 1(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 210nMAssay Description:Inhibition of FAK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Ribosomal protein S6 kinase alpha-3(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 182nMAssay Description:Inhibition of RSK2 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Misshapen-like kinase 1(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 115nMAssay Description:Inhibition of MINK1 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair

PDB MMDB KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Mitogen-activated protein kinase 8(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.13E+3nMAssay Description:Inhibition of JNK1 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Mitogen-activated protein kinase 9(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.10E+3nMAssay Description:Inhibition of JNK2 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Mitogen-activated protein kinase 10(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.00E+4nMAssay Description:Inhibition of JNK3 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Focal adhesion kinase 1(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 90nMAssay Description:Inhibition of FAK (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Ribosomal protein S6 kinase alpha-1(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 82nMAssay Description:Inhibition of RSK1 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Ribosomal protein S6 kinase alpha-3(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 80nMAssay Description:Inhibition of RSK2 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Ribosomal protein S6 kinase alpha-2(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 61nMAssay Description:Inhibition of RSK3 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) at 1 uM by kinomescan methodMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 5nMAssay Description:Inhibition of DYRK1B (unknown origin) at 1 uM by kinomescan methodMore data for this Ligand-Target Pair

PDB
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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Platelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.00E+4nMMore data for this Ligand-Target Pair

MMDB KEGG
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Casein kinase I isoform epsilon(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Dual specificity protein kinase CLK1(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.12E+3nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Dual specificity protein kinase CLK2(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 2.50E+3nMMore data for this Ligand-Target Pair

PDB
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Dual specificity protein kinase CLK3(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.00E+4nMMore data for this Ligand-Target Pair

PDB
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Dual specificity protein kinase CLK4(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 26nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 3.01E+3nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Dual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.10E+3nMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway KEGG
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Dual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Dual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 1.00E+4nMMore data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
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Glycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 3.40E+3nMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 154nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 367nMMore data for this Ligand-Target Pair

PDB
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

Kd: 1.20nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity protein kinase CLK1(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

Kd: 42nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

BDBM50585046(CHEMBL5086263)copy SMILES

IC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2183BDBPubMed

Targets 24 ▿
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 5
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 4
- Ribosomal protein S6 kinase alpha-3 2
- Dual specificity protein kinase CLK1 2
- Focal adhesion kinase 1 2
- Glycogen synthase kinase-3 beta 2
- Mitogen-activated protein kinase kinase kinase 19 1
- Platelet-derived growth factor receptor alpha/beta 1
- Mitogen-activated protein kinase 10 1
- Mitogen-activated protein kinase 9 1
- Misshapen-like kinase 1 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- Ribosomal protein S6 kinase alpha-6 1
- Mitogen-activated protein kinase 8 1
- Ribosomal protein S6 kinase alpha-2 1
- Ribosomal protein S6 kinase alpha-1 1
- Dual specificity mitogen-activated protein kinase kinase 4 1
- Serine/threonine-protein kinase Sgk1 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 4 1
- Casein kinase I isoform epsilon 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
Publications 0 ▿
Institutions 0 ▿
Affinity: 1.2 to 1.0E+4 nM▿
- IC50 32
- Kd 3
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1